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Resmetirom significantly reduced ALT (MD 15.71, 95% CI: 23.30 to 8.13), AST (MD 12.28, 95% CI: 21.07 to 3.49), and GGT (MD 19.56, 95% CI: 34.68 to 4.44)

In rare cases, they may also increase the risk of pancreatitis or gallbladder problems

Subsequent studies also examining data from the FDA Adverse Event Reporting System (FDA AERS) reported an increase in reporting rates of PDAC cases in GLP-1RA users over a broader study period 33,34

22 Taken together, these mixed results tell us that we need to be careful about picking the right patients, develop good biomarkers, and pay attention to drug specific properties in future studies

While some preclinical research has explored potential immunomodulatory effects of GLP-1 receptor agonists, there is currently insufficient clinical evidence to establish this as a mechanism for systemic symptoms in patients taking tirzepatide